HMGCR Ab Necrotizing autoimmune myopathy (NAM)

HMGCR Antibody (PA5-37367) in WB Western blot analysis of HMGCR in extracts of various cells using HMGCR polyclonal antibody (Product # PA5-37367).

Recently, auto-antibodies (AAbs) to the enzyme, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) was shown to be a MSA that was strongly associated with immune mediated necrotising myopathy (Arthritis Rheum. 2010 Sep;62(9):2757-66. doi: 10.1002/art.27572). HMGCR AAb positive patients present with progressive, irritable myopathy of the proximal HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is also named as HMG-CoA reductase and belongs to the HMG-CoA reductase family.

Anti-HMGCR antibody produced in rabbit Prestige Antibodies ® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution Synonym: Anti-3-Hydroxy-3-methylglutaryl-CoA reductase Human Protein Atlas Number HPA008338 Human Protein Atlas - View RNA & protein expression data of this target 2016-10-01 · Anti-HMGCR antibodies showed good discrimination between (a) immune-mediated necrotizing myopathies (IMNM) and all controls (except idiopathic inflammatory myopathies (IIM)), (b) IMNM and all controls, (c) IMNM vs. IIM. (d) Moderate discrimination was also found for all IIM (including IMNM) vs. all controls. Select HMGCR antibodies from monoclonal antibodies listed below. View detailed HMGCR antibody specifications by linking to the specific product blocks.

Rabbit Polyclonal HMGCR antibody. Validated in WB, ICC/IF, IHC-P. Tested in Human, Mouse, Rat. Cited in 1 reference(s).

Anti-HMGCR antibody (STJ24046) St John's Labs Immunohistochemistry of paraffin-embedded human uterine cancer using HMGCR antibody (STJ24046) at dilution of 1:200 (40x lens). Rabbit Polyclonal HMGCR antibody. Validated in WB, ICC/IF, IHC-P. Tested in Human, Mouse, Rat. Cited in 1 reference(s).

Nov 25, 2019 a diagnostic alert that anti-HMGCR related immune mediated necrotizing myopathy should (HMGCR) antibody, which was strongly positive.

免疫原: A synthesized peptide derived from human HMGCR, corresponding to a region within N-terminal amino acids. RRID: AB_2838480 引用格式: Affinity Biosciences Cat# DF6518, RRID:AB_2838480. 形式: Liquid. 浓度: 1mg/ml.

Mar 5, 2021 Complete information for HMGCR gene (Protein Coding), 3-Hydroxy-3- Methylglutaryl-CoA Reductase, including: function, proteins, disorders, Feb 25, 2020 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and antisignal recognition particle (SRP) antibodies are frequently associated May 1, 2019 IgG antibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are mainly associated with necrotizing autoimmune myopathy ANTI-HMGCR ANTIBODIES. Test Code HMGCR ABS Alias/See Also 3-Hydroxy- 3-Methylglutaryl Coenzyme A Reductase (HMGCR) Antibody, IgG. BILL CODE: Aug 14, 2018 The presence of anti-HMGCR antibodies, in conjunction with clinical findings and other laboratory tests, is an aid in the diagnosis of idiopathic May 27, 2020 Anti-HMGCR autoantibodies can be used not only for diagnosis, but also as a marker of disease activity.
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Concentration: 1mg/ml. Storage Condition and Buffer: Cites: Anti-HMGCR Antibody (A1633) Abstract: miRNAs are involved in many physiologic and disease processes by virtue of degrading specific mRNAs or inhibiting their translation. miR-148a has been implicated in the control of tumor growth and cholesterol and triglyceride homeostasis using in vitro or in vivo gene expression- and silencing-based approaches. Mouse Monoclonal Anti-HMGCR Antibody against Human 3-hydroxy-3-methylglutaryl-CoA reductase.

Immunogen … IgG antibodies to HMGCR in the setting of muscle weakness and a raised CK are highly suggestive of an autoimmune necrotising myositis. Many cases are associated with statin exposure although this is not universal.
Disseminated intravascular coagulation

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3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (HMGCR) Antibody (IgG) - 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (HMGCR) antibody is associated with necrotizing myopathy and is often associated with the use of statin medications.

Diseases associated with HMGCR include Familial Hyperlipidemia and Sitosterolemia.Among its related pathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and … HMGCR antibodies; LDLCQ3 antibodies; Custom Antibodies. If you can't find the antibody you're looking for, why not consider a custom reagent from one of these suppliers.

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Immunofluorescence analysis of A549 cell using HMGCR antibody. Blue: DAPI for nuclear staining. Rabbit anti-HMGCR Antibody.

Show Additional Columns. Antibody properties References Host Reactivity Antibody type Conjugate 2015-08-01 Monoclonal Anti-HMGCR antibody produced in mouse Prestige Antibodies ® Powered by Atlas Antibodies, clone CL0260, purified immunoglobulin, buffered aqueous glycerol solution : human: immunohistochemistry, western blot pricing 2016-10-01 Rabbit Polyclonal HMGCR antibody. Validated in WB, ICC/IF, IHC-P. Tested in Human, Mouse, Rat. Cited in 1 reference(s).

HMGCR, or both: a 2 x 2 factorial Mendelian rando- in PCSK9 and HMGCR and risk of cardiovascular antidrug-antibody formation with bococizumab.

It is reactive with 3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34; UniProt P00347; also known as HMG-CoA reductase) is encoded by the HMGCR gene (Gene ID anti-HMGCR Antibody reacting with Rabbit and identified with ELISA, WB, IHC, IF . Quality is guaranteed. Immunofluorescence analysis of A549 cell using HMGCR antibody. Blue: DAPI for nuclear staining. Rabbit anti-HMGCR Antibody. Rabbit polyclonal anti-HMGCR antibody (STJ24046) is suitable for use in Western Blot and Immunohistochemistry. Rabbit Polyclonal HMGCR antibody for IHC, WB. Published in 2 Pubmed References.

RRID: AB_2838480 引用格式: Affinity Biosciences Cat# DF6518, RRID:AB_2838480. 形式: Liquid.